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St. Louis ( or ) is the second-largest city in Missouri, and sits on the western bank of the Mississippi River, which forms the state line between Illinois and Missouri. The Missouri River merges with the Mississippi River 15 river miles north of Downtown St. Louis, forming the fourth-longest river system in the world. In 2019, the estimated population was 300,576, and of the bi-state metropolitan area, 2,804,724. Greater St. Louis is the largest metropolitan area in Missouri, second-largest in Illinois, seventh-largest in the Great Lakes Megalopolis, and the 22nd-largest in the United States.
Before European settlement, the area was a regional center of Native American Mississippian culture. The city of St. Louis was founded in February 14th of 1764 by French fur traders Gilbert Antoine de St. Maxent, Pierre Laclède and Auguste Chouteau, and named after Louis IX of France. In 1764, following France's defeat in the Seven Years' War, the area was ceded to Spain. In 1800, it was retroceded to France, which sold it three years later to the United States as part of the Louisiana Purchase. In the 19th century, St. Louis became a major port on the Mississippi River; in 1870, it was the fourth-largest city in the country. It separated from St. Louis County in 1877, becoming an independent city and limiting its own political boundaries. St. Louis had a brief run as a world-class city in the early 20th century. In 1904, it hosted the Louisiana Purchase Exposition and the Summer Olympics.
A "Gamma" global city with a metropolitan GDP of more than $160 billion in 2017, metropolitan St.
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Heidelberg ( HY-dəl-burg, German: [ˈhaɪdl̩bɛʁk] (listen)) is a university town in the German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. In the 2016 census, its population was 159,914, of which roughly a quarter consisted of students.Located about 78 km (48 mi) south of Frankfurt, Heidelberg is the fifth-largest city in Baden-Württemberg. Heidelberg is part of the densely populated Rhine-Neckar Metropolitan Region.
Heidelberg University, founded in 1386, is Germany's oldest and one of Europe's most reputable universities. Heidelberg is a scientific hub in Germany and home to several internationally renowned research facilities adjacent to its university, including the European Molecular Biology Laboratory and four Max Planck Institutes.